Article

Paroxetine attenuates osteoarthritis progression by regulating chondrocyte pyroptosis and inhibiting osteoclast formation

2022-11-29

Abstract excerpt

<h4>Background: </h4> Osteoarthritis (OA), a common chronic joint disease, is characterized by cartilage degeneration and subchondral bone reconstruction. Nuclear factor kappa-B (NF-κB) signaling pathway-activated inflammation and NLR family pyrin domain containing 3 (NLRP3)-induced pyroptosis play essential roles in the development of OA. In this study, we examine whether paroxetine, a well-known selective reupta...

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Literature Corpus work: 1926acb4-203f-518a-b559-1038a366d105
DOI: 10.21203/rs.3.rs-2253338/v1

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