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Article

Natural polyamines inhibit the migration of preosteoclasts by attenuating Ca2+-PYK2-Src-NFATc1 signaling pathways.

Amino acids - 1 Nov 2014

Yeon Jeong-Tae, Ryu Byung Jun, Choi Sik-Won, Heo Jin-Chul, Kim Kwang-Jin, Son Young-Jin, Kim Seong Hwan

Abstract excerpt

Natural polyamines have numerous biological activities. Several studies have reported their beneficial role in bone metabolism, but their mode of action is not fully understood. Bone diseases such as osteoporosis, which is characterized by impaired bone structure and low bone mass, are caused by an increased number of osteoclasts and/or overactivation of osteoclastogenesis. Osteoclast differentiation is a...

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PMID: 25216923
DOI: 10.1007/s00726-014-1797-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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