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Aberrant Tryptophan Metabolism Manipulates Osteochondral Homeostasis

1 Jan 2025

Abstract excerpt

Tryptophan (Trp), an essential amino acid, performs as a precursor for synthesizing various bioactive molecules primarily metabolized through the kynurenine (Kyn), serotonin, and indole pathways. The diverse metabolites were deeply implicated in multiple physiological processes. Emerging research has revealed the multifaceted contribution of Trp in skeletal health and pathophysiology of bone-related disease with...

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PMID: 40496774
DOI: 10.34133/research.0728

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