Article

Activation of KYN-AHR axis impairs the chondrogenic and chondroprotective effects of human umbilical cord-derived mesenchymal stem cells on osteoarthritis

2022-03-23

Abstract excerpt

<h4>Background: </h4> It has been proved that intra-articular injection of mesenchymal stem cells (MSCs) could alleviate cartilage damage of osteoarthritis (OA) via differentiating into chondrocytes or protecting inherent cartilage. However, how OA articular microenvironment could affect MSCs’ chondrogenic and chondroprotective efficiency has yet to be fully demonstrated. Tryptophan (Trp) metabolites, most of whic...

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Literature Corpus work: 15edf217-7b69-51af-ad93-e84cb6c9d934
DOI: 10.21203/rs.3.rs-1440407/v1

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