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Article

NLRP3 Inflammasome-Mediated Osteoarthritis: The Role of Epigenetics

14 Jan 2025

Abstract excerpt

The prevalence of osteoarthritis (OA) notably surges with age and weight gain. The most common clinical therapeutic drugs are painkillers, yet they cannot impede the deteriorating course of OA. Thus, understanding OA’s pathogenesis and devising effective therapies is crucial. It is generally recognized that inflammation, pyroptosis, and OA progression are tightly linked. The activation of NLRP3 inflammasome can...

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PMID: 39857301
DOI: 10.3390/biology14010071

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