Article

Alpinetin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss by Modulating NFATc1 Transcription and Lysosomal Function

2020-12-28

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Postmenopausal osteoporosis is a chronic metabolic bone disease caused by excessive osteoclast activation, and osteoclasts are considered to be the sole participants in the degeneration and resorption of bone matrix for controlling bone integrity and continuity. The biological functions of osteoclasts depend critically on the number and activity of fused polykaryo...

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Literature Corpus work: 544a089b-4865-50dc-872b-4712640de5a4
DOI: 10.21203/rs.3.rs-132706/v1

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