Article

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

2024-04-03

Abstract excerpt

<h4>Summary</h4> Rheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role of FLS circadian clock function in directing rhythmic joint inflammation in a murine model of inflammatory arthritis. We demonstrate FLS time of day...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1926a110-29fa-5c32-80b7-ee4a6c8e6083
DOI: 10.1101/2024.04.02.587439

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritisDOI 10.1101/2024.04.02.587439Read

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritisSemantic proximity Read

Rheumatoid arthritis reprograms circadian output pathwaysSemantic proximity Read

Circadian Clock: A Regulator of Immunity in Autoimmune DiseasesSemantic proximity Read

Mammalian <i>Clock</i> Gene <i>Cryptochrome</i> Regulates Arthritis via Proinflammatory Cytokine TNF-αSemantic proximity Read

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.Semantic proximity Read

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integritySemantic proximity Read

The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genesSemantic proximity Read

Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritisSemantic proximity Read

Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritisSemantic proximity Read

Fibroblast pathology in inflammatory joint diseaseSemantic proximity Read

Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onsetSemantic proximity Read

Regulatory T cells confer a circadian signature on inflammatory arthritisSemantic proximity Read