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Article

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.

Epigenomics - 1 Apr 2017

Doody Karen M, Bottini Nunzio, Firestein Gary S

Abstract excerpt

Rheumatoid arthritis is an immune-mediated disease that primarily affects diarthrodial joints. Susceptibility and severity of this disease are influenced by nongenetic factors, such as environmental stress, suggesting an important role of epigenetic changes. In this review, we summarize the epigenetic changes (DNA methylation, histone modification and miRNA expression) in fibroblast-like synoviocytes, which are...

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Identifiers

PMID: 28322585
DOI: 10.2217/epi-2016-0151
PMCID: PMC5549652

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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