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Article

Rheumatoid arthritis reprograms circadian output pathways

6 Feb 2019

Abstract excerpt

OBJECTIVE: We applied systems biology approaches to investigate circadian rhythmicity in rheumatoid arthritis (RA). METHODS: We recruited adults (age 16-80 years old) with a clinical diagnosis of RA (active disease [DAS28 > 3.2]). Sleep profiles were determined before inpatient measurements of saliva, serum, and peripheral blood mononuclear leukocytes (PBML). Transcriptome and proteome analyses were carried out...

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PMID: 30728072
DOI: 10.1186/s13075-019-1825-y

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