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Article

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

1 Jul 2024

Abstract excerpt

Abstract Rheumatoid arthritis is a chronic inflammatory disease that shows characteristic diurnal variation in symptom severity, where joint resident fibroblast-like synoviocytes (FLS) act as important mediators of arthritis pathology. We investigate the role of FLS circadian clock function in directing rhythmic joint inflammation in a murine model of inflammatory arthritis. We demonstrate FLS...

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PMID: 38981514
DOI: 10.1098/rsob.240089

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