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Article

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

13 Dec 2015

Abstract excerpt

Osteoarthritis (OA) is the most prevalent and debilitating joint disease, and there are currently no effective disease-modifying treatments available. Multiple risk factors for OA, such as aging, result in progressive damage and loss of articular cartilage. Autonomous circadian clocks have been identified in mouse cartilage, and environmental disruption of circadian rhythms in mice predisposes animals to OA-like...

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PMID: 26657859
DOI: 10.1172/jci82755

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