Article

The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genes

2025-09-19

Abstract excerpt

Disruption of circadian rhythms predisposes shift workers to many chronic conditions, including osteoporosis. However, the effects of disrupted circadian rhythms on bone remodeling remain largely unknown. Here, we show that one of the core circadian regulators PER1 inhibits osteoclastogenesis by upregulating genes involved in inflammation. The conditional knockout of Per1 in osteoclasts and related cells resulted...

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Identifiers and source

Literature Corpus work: aeeab938-0766-53cd-80cb-fc444e4aaa0a
DOI: 10.1101/2025.09.18.677145

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