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Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis

23 May 2024

Abstract excerpt

Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component in the inflamed synovium of patients with rheumatoid arthritis (RA). FLSs are emerging as promising new therapeutic targets in RA. However, fibroblasts perform many essential functions that are required for sustaining tissue homeostasis. Direct targeting of general fibroblast markers on FLSs is...

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PMID: 38783357
DOI: 10.1186/s13075-024-03343-4

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