Article

Refining a Mouse Model of Progressive Supranuclear Palsy Through Inoculation of Human Post-Mortem Brain-Derived Tau

2025-09-12

Abstract excerpt

<title>Abstract</title> <p>Objective A major obstacle to developing effective therapies for Progressive Supranuclear Palsy (PSP), a uniformly fatal 4R tauopathy, is the absence of an animal model that faithfully reproduces the anatomical, cytopathological, and spatiotemporal progression of disease. Inoculation-based models, using human postmortem brain material bearing disease-specific proteopathic tau seeds, hol...

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Literature Corpus work: 1923fd12-a3e6-5e70-94f0-1ba276b8f5b0
DOI: 10.21203/rs.3.rs-7456824/v1

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