Article

4R-Tau seeding activity unravels molecular subtypes in patients with Progressive Supranuclear Palsy

2023-09-29

Abstract excerpt

Progressive Supranuclear palsy (PSP) is a 4-repeat (4-R) tauopathy. We hypothesized that the molecular diversity of tau could explain the heterogeneity seen in PSP disease progression. To test this hypothesis, we performed an extensive biochemical characterisation of the high molecular weight tau species (HMW-Tau) in 20 different brain regions of 25 PSP patients. We found a correlation between the HMW-Tau species...

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Literature Corpus work: f5a7fe5a-cb72-505b-92e0-5cf2df023e66
DOI: 10.1101/2023.09.28.559953

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