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Article

Characterization of tau oligomeric seeds in progressive supranuclear palsy

14 Jun 2014

Abstract excerpt

BACKGROUND: Progressive supranuclear palsy (PSP) is a neurodegenerative tauopathy which is primarily defined by the deposition of tau into globose-type neurofibrillary tangles (NFT). Tau in its native form has important functions for microtubule dynamics. Tau undergoes alternative splicing in exons 2, 3, and 10 which results in six different isoforms. Products of splicing on exon 10 are the most prone to...

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PMID: 24927818
DOI: 10.1186/2051-5960-2-73

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