Article
A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin.
Investigative ophthalmology & visual science - 1 Dec 2007
Brill Elliott, Malanson Katherine M, Radu Roxana A, Boukharov Natalia V, Wang Zhongyan, Chung Hae-Yun, Lloyd Marcia B, Bok Dean, Travis Gabriel H, Obin Martin, Lem Janis
Abstract excerpt
PURPOSE: Rhodopsin mutations account for approximately 25% of human autosomal dominant retinal degenerations. However, the molecular mechanisms by which rhodopsin mutations cause photoreceptor cell death are unclear. Mutations in genes involved in the termination of rhodopsin signaling activity have been shown to cause degeneration by persistent activation of the phototransduction cascade. This study examined...
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