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Article

HSPA1A conformational mutants reveal a conserved structural unit in Hsp70 proteins.

Biochimica et biophysica acta. General subjects - 1 Jan 2020

Vandova Veronika, Vankova Pavla, Durech Michal, Houser Josef, Kavan Daniel, Man Petr, Muller Petr, Trcka Filip

Abstract excerpt

BACKGROUND: The Hsp70 proteins maintain proteome integrity through the capacity of their nucleotide- and substrate-binding domains (NBD and SBD) to allosterically regulate substrate affinity in a nucleotide-dependent manner. Crystallographic studies showed that Hsp70 allostery relies on formation of contacts between ATP-bound NBD and an interdomain linker, accompanied by SBD subdomains docking onto distinct sites...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31676290
DOI: 10.1016/j.bbagen.2019.129458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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