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Article

Activation mechanism of small heat shock protein HSPB5 revealed by disease-associated mutants.

Proceedings of the National Academy of Sciences of the United States of America - 20 May 2025

Woods Christopher N, Janowska Maria K, Ulmer Lindsey D, Kaur Sidhu Jasleen, Stone Natalie L, James Ellie I, Guttman Miklos, Bush Matthew F, Klevit Rachel E

Abstract excerpt

Found from bacteria to humans, small heat shock proteins (sHSPs) are the least understood protein chaperones. HSPB5 (or αB-crystallin) is among the most widely expressed of the 10 human sHSPs, including in muscle, brain, and eye lens where it is constitutively present at high levels. A high content of disorder in HSPB5 has stymied efforts to uncover how its structure gives rise to function. To uncover its...

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PMID: 40377988
DOI: 10.1073/pnas.2425061122
PMCID: PMC12107100

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