Article

Mixed Model with Correction for Case-Control Ascertainment Increases Association Power

2014-09-04

Abstract excerpt

We introduce a Liability Threshold Mixed Linear Model (LTMLM) association statistic for ascertained case-control studies that increases power vs. existing mixed model methods, with a well-controlled false-positive rate. Recent work has shown that existing mixed model methods suffer a loss in power under case-control ascertainment, but no solution has been proposed. Here, we solve this problem using a chi-square sc...

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Literature Corpus work: 18ff7288-bc23-5218-9a17-a02be82f784b
DOI: 10.1101/008755

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