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Article

Efficient generalized least squares method for mixed population and family-based samples in genome-wide association studies.

Genetic epidemiology - 1 Jul 2014

Li Jia, Yang James, Levin Albert M, Montgomery Courtney G, Datta Indrani, Trudeau Sheri, Adrianto Indra, McKeigue Paul, Iannuzzi Michael C, Rybicki Benjamin A

Abstract excerpt

Genome-wide association studies (GWAS) that draw samples from multiple studies with a mixture of relationship structures are becoming more common. Analytical methods exist for using mixed-sample data, but few methods have been proposed for the analysis of genotype-by-environment (G×E) interactions. Using GWAS data from a study of sarcoidosis susceptibility genes in related and unrelated African Americans, we...

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PMID: 24845555
DOI: 10.1002/gepi.21811
PMCID: PMC4112407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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