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Article

Mixed logistic regression in genome-wide association studies.

BMC bioinformatics - 23 Nov 2020

Milet Jacqueline, Courtin David, Garcia André, Perdry Hervé

Abstract excerpt

BACKGROUND: Mixed linear models (MLM) have been widely used to account for population structure in case-control genome-wide association studies, the status being analyzed as a quantitative phenotype. Chen et al. proved in 2016 that this method is inappropriate in some situations and proposed GMMAT, a score test for the mixed logistic regression (MLR). However, this test does not produces an estimation of the...

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PMID: 33228527
DOI: 10.1186/s12859-020-03862-2
PMCID: PMC7684894

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