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Article

Mixed model with correction for case-control ascertainment increases association power.

American journal of human genetics - 7 May 2015

Hayeck Tristan J, Zaitlen Noah A, Loh Po-Ru, Vilhjalmsson Bjarni, Pollack Samuela, Gusev Alexander, Yang Jian, Chen Guo-Bo, Goddard Michael E, Visscher Peter M, Patterson Nick, Price Alkes L

Abstract excerpt

We introduce a liability-threshold mixed linear model (LTMLM) association statistic for case-control studies and show that it has a well-controlled false-positive rate and more power than existing mixed-model methods for diseases with low prevalence. Existing mixed-model methods suffer a loss in power under case-control ascertainment, but no solution has been proposed. Here, we solve this problem by using a χ(2)...

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Identifiers

PMID: 25892111
DOI: 10.1016/j.ajhg.2015.03.004
PMCID: PMC4570278

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PML

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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