Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in Bacteroides thetaiotaomicron important for envelope integrity and fitness

Abstract excerpt

<title>Abstract</title> <p>Serine hydrolases play important roles in signaling and human metabolism, yet little is known about the functions of these enzymes in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal <italic>Bacteroides thetaiotaomicron</italic> that are specific to the Bacteroidetes phylum. Two are predicted homologs of the human prote...

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• Clostridium difficile and Clostridium perfringens research
• Diabetes Treatment and Management
• Diet and metabolism studies
• Gut microbiota and health
• Helicobacter pylori-related gastroenterology studies
• Neuropeptides and Animal Physiology
• Peptidase Inhibition and Analysis
• Probiotics and Fermented Foods

Identifiers and source

Literature Corpus work

18fa3186-546e-51d2-b0a9-df05dabdd717

DOI

10.21203/rs.3.rs-1918112/v1