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Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in <i>Bacteroides thetaiotaomicron</i> important for envelope integrity and fitness

2022-07-26

Abstract excerpt

Serine hydrolases play important roles in signaling and human metabolism, yet little is known about the functions of these enzymes in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal Bacteroides thetaiotaomicron that are specific to the Bacteroidetes phylum. Two are predicted homologs of the human protease dipeptidyl peptidase 4 (hDPP4), a key en...

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Literature Corpus work
29e6dbff-7ee8-5f5d-b8c2-b9cdd638b12a
DOI
10.1101/2022.07.25.501481
Open publication

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Chemoproteomic identification of a dipeptidyl peptidase 4 (DPP4) homolog in <i>Bacteroides thetaiotaomicron</i> important for envelope integrity and fitnessDOI 10.1101/2022.07.25.501481
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