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Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target

3 Aug 2023

Abstract excerpt

A mechanistic understanding of how microbial proteins affect the host could yield deeper insights into gut microbiota-host cross-talk. We developed an enzyme activity-screening platform to investigate how gut microbiota-derived enzymes might influence host physiology. We discovered that dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 was able to decrease the...

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PMID: 37535747
DOI: 10.1126/science.add5787

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