Sequence and Structural Analysis of human gut microbial Prolyl Oligopeptidases (POPs): towards design of therapeutics for Celiac Disease

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Celiac Disease (CD) is a common autoimmune disorder where the patients are unable to digest gluten, which is present in foods made up of wheat, barley and rye. Whilst diagnosis happens late in 80% of the cases, avoidance of such foods appears to be the common solution. Alternative management strategies are required for the patients and their families since CD is...

Topics

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• Biocatalysis
• Celiac Disease
• Hydrolysis
• Models, Molecular
• Molecular Structure
• Mutation
• Peptides
• Protein Engineering

Identifiers and source

Literature Corpus work

f4187fba-c6ce-5286-9e60-c606209403c0

DOI

10.21203/rs.3.rs-3972746/v1