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Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes

2 Apr 2025

Abstract excerpt

Human dipeptidyl peptidase 4 (hDPP-4) has been a pharmacological target for metabolic diseases, particularly diabetes, since the early 2000s. As a ubiquitous enzyme found in both prokaryotic and eukaryotic organisms, hDPP-4 plays crucial roles in host homeostasis and disease progression. While many studies have explored hDPP-4's properties, research on gut microbially derived DPP-4 (mDPP-4) remains limited. This...

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PMID: 40173242
DOI: 10.1126/sciadv.ads5721

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