Identification of commensals and molecular components mediating trypsin degradation in the large intestine

Abstract excerpt

<title>Abstract</title> <p>The gastrointestinal tract is constitutively exposed to proteases including trypsin, a serine protease originating from the pancreas1. Elevated trypsin levels in the large intestine have been implicated in pathological conditions including infectious and inflammatory bowel disease2-4. Here we show that trypsin is regulated via degradation by members of the gut microbiota. After passing...

Topics

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• Amoebic Infections and Treatments
• Celiac Disease Research and Management
• Genomics and Phylogenetic Studies
• Helicobacter pylori-related gastroenterology studies
• Microscopic Colitis
• Oral microbiology and periodontitis research
• Peptidase Inhibition and Analysis
• Salmonella and Campylobacter epidemiology

Identifiers and source

Literature Corpus work

4c4302a0-f3be-5c1e-952a-44ec4ca879cd

DOI

10.21203/rs.3.rs-774361/v1