Article

Mismatch Repair Status Characterization in Oncologic Pathology: Taking Stock of the Real-World Possibilities

2021-04-01

Abstract excerpt

The mismatch repair (MMR) system has a key role in supporting the DNA polymerase proofreading function and in maintaining genome stability. Alterations in the MMR genes are driving events of tumorigenesis, tumor progression, and resistance to therapy. These genetic scars may occur in either hereditary or sporadic settings, with different frequencies across tumor types. Appropriate characterization of the MMR statu...

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Literature Corpus work: 18ee8c5a-33de-5d2c-b98d-f83bac500b72
DOI: 10.3390/jmp2020009

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