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Article

The role of DNA mismatch repair in immunotherapy of human cancer.

International journal of biological sciences - 1 Jan 2022

He Yuchen, Zhang Luyuan, Zhou Ruoyu, Wang Yumin, Chen Hao

Abstract excerpt

DNA mismatch repair (MMR) is an important pathway which helps to maintain genomic stability. Mutations in DNA MMR genes are found to promote cancer initiation and foster tumor progression. Deficiency or inactivation of MMR results in microsatellite instability (MSI) which triggers neoantigen generation and impairs tumor growth. Immunotherapies targeting MMR can increase the burden of neoantigens in tumor cells....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35541922
DOI: 10.7150/ijbs.71714
PMCID: PMC9066103

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