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Advances in diagnostic and therapeutic applications of mismatch repair loss in cancer

27 Feb 2025

Abstract excerpt

Mismatch repair (MMR) is a highly conserved, fundamental DNA damage repair pathway that maintains genomic fidelity during cell replication. MMR dysregulation contributes to tumor formation by promoting genomic instability thereby increasing the frequency of potentially oncogenic mutational events. Therefore, MMR dysregulation, in its tumor suppressor role, is largely studied in the context of genomic instability...

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PMID: 40068557
DOI: 10.1016/j.dnarep.2025.103822

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