Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice.

doi:10.1172/JCI166134

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Article

Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice.

The Journal of clinical investigation - 16 Jan 2024

Romay Milagros C, Knutsen Russell H, Ma Feiyang, Mompeón Ana, Hernandez Gloria E, Salvador Jocelynda, Mirkov Snezana, Batra Ayush, Sullivan David P, Procissi Daniele, Buchanan Samuel, Kronquist Elise, Ferrante Elisa A, Muller William A, Walshon Jordain, Steffens Alicia, McCortney Kathleen, Horbinski Craig, Tournier-Lasserve Elisabeth, Sonabend Adam M, Sorond Farzaneh A, Wang Michael M, Boehm Manfred, Kozel Beth A, Iruela-Arispe M Luisa

Abstract excerpt

Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in both murine and human brain vessels. To clarify the consequences of...

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Identifiers

PMID: 38015629
DOI: 10.1172/JCI166134
PMCID: PMC10786701

Genes

NOTCH3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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