Article
Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2011
Park Hyun Woo, Kim Joo Young, Choi Soo-Kyoung, Lee Young-Ho, Zeng Weizhong, Kim Kyung Hwan, Muallem Shmuel, Lee Min Goo
Abstract excerpt
Mutations in the serine-threonine kinase with-no-lysine 4 (WNK4) cause pseudohypoaldosteronism type 2 (PHAII), a Mendelian form of human hypertension. WNK4 regulates diverse ion transporters in the kidney, and dysregulation of renal transporters is considered the main cause of the WNK4 mutation-associated hypertension. Another determinant of hypertension is vascular tone that is regulated by Ca(2+)-dependent...
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