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Article

Reducing Hypermuscularization of the Transitional Segment Between Arterioles and Capillaries Protects Against Spontaneous Intracerebral Hemorrhage.

Circulation - 23 Jun 2020

Ratelade Julien, Klug Nicholas R, Lombardi Damiano, Angelim Monara Kaelle Servulo Cruz, Dabertrand Fabrice, Domenga-Denier Valérie, Al-Shahi Salman Rustam, Smith Colin, Gerbeau Jean-Frédéric, Nelson Mark T, Joutel Anne

Abstract excerpt

BACKGROUND: Spontaneous deep intracerebral hemorrhage (ICH) is a devastating subtype of stroke without specific treatments. It has been thought that smooth muscle cell (SMC) degeneration at the site of arteriolar wall rupture may be sufficient to cause hemorrhage. However, deep ICHs are rare in some aggressive small vessel diseases that are characterized by significant arteriolar SMC degeneration. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32183562
DOI: 10.1161/CIRCULATIONAHA.119.040963
PMCID: PMC7311305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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