Fragile X Mental Retardation Protein regulates R-loop formation and prevents global chromosome fragility

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X syndrome (FXS) is the most prevalent inherited intellectual disability caused by mutations in the Fragile X Mental Retardation 1 ( FMR1 ) gene. The protein product of FMR1 , FMRP, is known as a translational repressor whose nuclear function is not understood. Here we report that FMRP is a genome maintenance protein. We show that FX cells exhibit elevated level of chromosome breaks, b...

Topics

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• Aphidicolin
• Chromosome Breakage
• DNA Damage
• DNA Replication
• Fragile X Mental Retardation Protein
• Fragile X Syndrome
• RNA
• Stress, Physiological

Identifiers and source

Literature Corpus work

0fbc23b9-9781-5fb2-8c36-485a5acb165d

DOI

10.1101/601906