Article

IFNγ-associated immune–metabolic remodeling drives serotonin–kynurenine imbalance with cortical vulnerability in lupus-prone mice

2025-11-19

Abstract excerpt

<h4>Introduction</h4> Neuropsychiatric systemic lupus erythematosus (NPSLE) is a major clinical challenge, characterized by heterogeneous manifestations and the absence of reliable biomarkers. The mechanisms linking systemic autoimmunity to neuronal injury and neuropsychiatric symptoms remain poorly understood. <h4>Methods</h4> Using the lupus-prone MRL/Lpr mouse model, we integrated systemic cytokine profiling,...

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Literature Corpus work: 18be3537-e999-5aa8-a706-5df37f8818c9
DOI: 10.1101/2025.11.19.689278

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