Article

A severely affected MRL/Lpr mouse exhibits a divergent clinical–immune profile associated with a profound metabolic alteration

2026-01-09

Abstract excerpt

Systemic lupus erythematosus (SLE) displays marked clinical and biological heterogeneity that is incompletely captured by group-based analyses. Although the MRL/Lpr mouse is a well-established lupus model, individual-level divergence within this genetically homogeneous strain remains poorly characterized. Here, we describe an MRL/Lpr mouse exhibiting an exceptionally severe systemic phenotype and provide an integr...

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Literature Corpus work: 8e62b6ae-0f43-596d-aa29-dc76d55f407a
DOI: 10.64898/2026.01.07.698139

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