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Article

Microglia-dependent synapse loss in type I interferon-mediated lupus.

Nature - 22 Jun 2017

Bialas Allison R, Presumey Jessy, Das Abhishek, van der Poel Cees E, Lapchak Peter H, Mesin Luka, Victora Gabriel, Tsokos George C, Mawrin Christian, Herbst Ronald, Carroll Michael C

Abstract excerpt

Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of patients with SLE experience neuropsychiatric symptoms that range from anxiety, depression and cognitive impairment to seizures and, in rare cases, psychosis-collectively this is referred to as central nervous system (CNS) lupus. In some...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28614301
DOI: 10.1038/nature22821

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