Article

Hippocampal multi-layered RNAseq prioritizes oligodendrocyte dysfunction over immune–driven neuroinflammation in neurolupus pathogenesis

2025-10-03

Abstract excerpt

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a severe manifestation of lupus marked by cognitive and mood disorders, yet its hippocampal molecular underpinnings remain poorly understood. Here, we provide a region-specific transcriptomic map of the hippocampus in MRL/Lpr mice —a validated NPSLE model— compared to MRL +/+ controls. Bulk RNA-seq combined with integrative analyses ( e.g. differential exp...

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Literature Corpus work: 4a41936e-391f-55ff-ba69-fc617bc029d2
DOI: 10.1101/2025.10.03.679744

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