Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus.

Frontiers in immunology - 1 Jan 2020

Makinde Hadijat M, Winter Deborah R, Procissi Daniele, Mike Elise V, Stock Ariel D, Kando Mary J, Gadhvi Gaurav T, Droho Steven, Bloomfield Christina L, Dominguez Salina T, Mayr Maximilian G, Lavine Jeremy A, Putterman Chaim, Cuda Carla M

Abstract excerpt

Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE) affect over one-half of SLE patients, yet underlying mechanisms remain largely unknown. We demonstrate that SLE-prone mice (CReCOM) develop NP-SLE, including behavioral deficits prior to systemic autoimmunity, reduced brain volumes, decreased vascular integrity, and brain-infiltrating leukocytes. NP-SLE microglia exhibit numerical expansion,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Association Learning
Share to Blood-Brain Barrier

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gray Matter

Share to Maze Learning

Share to Memory Disorders

Share to Mice, Inbred MRL lpr

Share to Reflex, Startle

Share to White Matter

Source

Open in PubMed Open full text

Identifiers

PMID: 32174913
DOI: 10.3389/fimmu.2020.00230
PMCID: PMC7055359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Microglia-Specific Transcriptional Signature Correlates With Behavioral Deficits in Neuropsychiatric Lupus.PMID 32174913Read ↗

Microglia-dependent synapse loss in type I interferon-mediated lupus.Semantic proximity Read ↗

Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal InflammationSemantic proximity Read ↗

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.Semantic proximity Read ↗

Lupus-prone B6.Nba2 male and female mice display anti-DWEYS reactivity and a neuropsychiatric phenotype.Semantic proximity Read ↗

Microglial responses to peripheral type 1 interferonSemantic proximity Read ↗

Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive DiseaseSemantic proximity Read ↗

Myeloid masquerade: Microglial transcriptional signatures in retinal development and diseaseSemantic proximity Read ↗

Systemic lupus erythematosus-accelerated atherosclerosis: mechanistic insights and clinical implications.Semantic proximity Read ↗

Phenotypic and functional alterations of peritoneal macrophages in lupus-prone mice.Semantic proximity Read ↗

Microglial brain region-dependent diversity and selective regional sensitivities to aging.Semantic proximity Read ↗

Non-pathogenic tissue-resident CD8+ T cells uniquely accumulate in the brains of lupus-prone mice.Semantic proximity Read ↗

Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.