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Article

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.

Scientific reports - 24 Jan 2017

Lanz Tobias V, Williams Sarah K, Stojic Aleksandar, Iwantscheff Simeon, Sonner Jana K, Grabitz Carl, Becker Simon, Böhler Laura-Inés, Mohapatra Soumya R, Sahm Felix, Küblbeck Günter, Nakamura Toshikazu, Funakoshi Hiroshi, Opitz Christiane A, Wick Wolfgang, Diem Ricarda, Platten Michael

Abstract excerpt

The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled by indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO). IDO is expressed in antigen presenting cells during immune reactions, hepatic TDO regulates blood homeostasis of tryptophan and neuronal TDO influences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28117398
DOI: 10.1038/srep41271
PMCID: PMC5259766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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