Back to search

Article

Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cells

2025-05-23

Abstract excerpt

Hepatitis C Virus (HCV) is a bloodborne virus that affects 57 million people globally with infections that can often go unnoticed, and it is the leading cause of chronic liver disease and cancer. Thus, development of an HCV vaccine is a major medical and public health concern. While prior work has developed secreted E1E2 (sE1E2) protein vaccine candidates, efforts to express it recombinantly in Chinese hamster ova...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
18a6d586-0c2c-576a-a3f6-4d4fa29d940c
DOI
10.1101/2025.05.20.655202
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cellsDOI 10.1101/2025.05.20.655202
Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein‐Protein Interaction Identification in Glycoengineered CHO CellsSemantic proximity
Sites of vulnerability in HCV E1E2 identified by comprehensive functional screeningSemantic proximity
Elucidation of the CHO Super-Ome (CHO-SO) by ProteoinformaticsSemantic proximity
Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesisSemantic proximity
Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.Semantic proximity
Hepatitis C Virus Envelope Glycoproteins: A Balancing Act of Order and DisorderSemantic proximity
Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteinsSemantic proximity
Network based analysis of hepatitis C virus Core and NS4B protein interactionsSemantic proximity
Optimised cell systems for the investigation of hepatitis C virus E1E2 glycoproteinsSemantic proximity
High yield expression and purification of Chikungunya virus E2 recombinant protein and its evaluation for serodiagnosisSemantic proximity
Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteinsSemantic proximity
A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques.Semantic proximity
Select a neighboring publication to make it the new centre.