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Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

18 Dec 2017

Abstract excerpt

The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technically challenging to study because of difficulties in producing natively folded proteins by standard protein expression and purification methods. To better comprehend the...

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PMID: 29253863
DOI: 10.1371/journal.ppat.1006735

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