Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein‐Protein Interaction Identification in Glycoengineered CHO Cells

1 Sept 2025

Abstract excerpt

Hepatitis C Virus (HCV) is a pervasive bloodborne virus and the leading cause of chronic liver disease and cancer. Thus, the development of an HCV vaccine is of great importance. Prior work has developed candidate vaccines, including more potent glycoengineered viral proteins and secreted forms of the E1E2 envelope heterodimer (sE1E2). However, efforts to express them recombinantly in Chinese hamster ovary (CHO)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40899434
DOI: 10.1002/biot.70112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein‐Protein Interaction Identification in Glycoengineered CHO CellsPMID 40899434Read ↗

Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cellsSemantic proximity Read ↗

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesisSemantic proximity Read ↗

Sites of vulnerability in HCV E1E2 identified by comprehensive functional screeningSemantic proximity Read ↗

Hepatitis C Virus Envelope Glycoproteins: A Balancing Act of Order and DisorderSemantic proximity Read ↗

Native Folding of a Recombinant gpE1/gpE2 Heterodimer Vaccine Antigen from a Precursor Protein Fused with Fc IgGSemantic proximity Read ↗

Network based analysis of hepatitis C virus Core and NS4B protein interactionsSemantic proximity Read ↗

Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteinsSemantic proximity Read ↗

Structure of the hepatitis C virus E1E2 glycoprotein complexSemantic proximity Read ↗

Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.Semantic proximity Read ↗

Rational design of hepatitis C virus E2 core nanoparticle vaccinesSemantic proximity Read ↗

Elucidating Novel Hepatitis C Virus–Host Interactions Using Combined Mass Spectrometry and Functional Genomics ApproachesSemantic proximity Read ↗

High yield expression and purification of Chikungunya virus E2 recombinant protein and its evaluation for serodiagnosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.