Article
Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007
Tarr Alexander W, Owsianka Ania M, Szwejk Alexandra, Ball Jonathan K, Patel Arvind H
Abstract excerpt
Hepatitis C virus (HCV) infection is a major cause of severe chronic liver disease including cirrhosis and hepatocellular carcinoma. HCV has been classified into six major genotypes that exhibit extensive genetic variability, particularly in the envelope glycoproteins E1 and E2. Knowledge of genotypic and quasispecies variation on viral glycoprotein properties is important in understanding the structure-function...
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