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A reflection on the improvement of Chinese hamster ovary cell-based bioprocesses through advances in proteomic techniques.

Biotechnology advances - 1 Jan 2000

Nguyen Melanie, Zimmer Aline

Abstract excerpt

Chinese hamster ovary (CHO) cells are the preferred mammalian host for the large-scale production of recombinant proteins in the biopharmaceutical industry. Research endeavors have been directed to the optimization of CHO-based bioprocesses to increase protein quantity and quality, often in an empirical manner. To provide a rationale for those achievements, a myriad of CHO proteomic studies has arisen in recent...

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PMID: 37001570
DOI: 10.1016/j.biotechadv.2023.108141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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