Article
Peptide switch is essential for Sirt1 deacetylase activity.
Molecular cell - 21 Oct 2011
Kang Hyeog, Suh Jeong-Yong, Jung Young-Sang, Jung Jae-Won, Kim Myung K, Chung Jay H
Abstract excerpt
In mammals, the Sirtuins are composed of seven Sir2 orthologs (Sirt1-7) with a conserved deacetylase core that utilizes NAD(+) as a cofactor. Interestingly, the deacetylase core of Sirt1 by itself has no catalytic activity. We found within the C-terminal domain a 25 aa sequence that is essential for Sirt1 activity (ESA). Our results indicate that the ESA region interacts with and functions as an "on switch" for...
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