Article

Lead Structure‐Based Hybridization Strategy Reveals Major Potency Enhancement of SirReal‐Type Sirt2 Inhibitors

2025-05-12

Abstract excerpt

Selective and potent inhibitors of the NAD+-dependent deacetylase Sirt2 represent a valuable epigenetic approach for the treatment of hitherto incurable diseases such as Parkinson's disease, Huntington’s disease, Alzheimer's disease and multiple sclerosis. Guided by docking studies, a lead structure-based hybridization concept was developed, resulting in a series of very effective Sirt2 inhibitors. With...

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Literature Corpus work: 95ca00c2-6c94-5d4a-b5ac-8d905a3b0282
DOI: 10.20944/preprints202505.0864.v1

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