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Article

Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.

PloS one - 1 Jan 2016

Yu Junru, Haldar Manas, Mallik Sanku, Srivastava D K

Abstract excerpt

Sirtuins are emerging as the key regulators of metabolism and aging, and their potential activators and inhibitors are being explored as therapeutics for improving health and treating associated diseases. Despite the global structural similarity among all seven isoforms of sirtuins (of which most of them catalyze the deacetylation reaction), SIRT5 is the only isoform that catalyzes the cleavage of negatively...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27023330
DOI: 10.1371/journal.pone.0152467
PMCID: PMC4811591

Genes

SIRT5
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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